People always ask: “Will CBD interact with other medications?” CBD is safe with a low potential for interacting with other supplements or drugs. There are some exceptions.

These exceptions mainly involve medications that affect the liver. The liver is an important and complex organ responsible for metabolizing many compounds from the body, including the naturally-made ones like blood cells and hormones. When you take large amounts of CBD with your other medication, that can overwhelm the liver and cause the other compounds that follow the same path of metabolism to become backed up. This might cause the effects of the drugs to last longer than expected, thereby increasing the chances of producing side effects.

Every drug is metabolized by different enzymes in the liver. If you are planning to use CBD in combination with any other medications, we recommend, that you ask your doctor if there are any known drug interactions with CBD. You can also lookup the specific enzymes that metabolize the drugs you are taking and then compare them to enzymes known to metabolize CBD. Below are the specific liver enzymes that metabolize CBD:

  • CYP1A1
  • CYP1A2
  • CTP1B1
  • CYP2B6
  • CYP2D6
  • CYP3A5

Other drugs that work off the same pathways may interfere with CBD. This can include endocannabinoid agonists or antagonists, or opioid medications, or adenosine inhibitors.

Always consult your physician before taking CBD along with your other medications.